Daniel Zhu
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Daniel Zhu

Software Developer

Research

Spateo: Spatiotemporal modeling of molecular holograms

November 11th, 2024, Cell
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Related: Mapping cells through space and time with moscot

Introduces multi-omics single-cell optimal transport (moscot), a scalable framework for optimal transport in single-cell genomics. This can be used to align mouse cells across space and time.

Related: A single-cell time-lapse of mouse prenatal development from gastrula to birth

This study established a single-cell atlas spanning 12.4 million nuclei from 83 embryos, precisely staged at 2- to 6-hour intervals spanning late gastrulation, annotating hundreds of cell types.

Defining the determinants of protection against SARS-CoV-2 infection and viral control in a dose-down Ad26. CoV2. S vaccine study in nonhuman primates

May 2nd, 2022, PLoS Biology
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Related: Compromised Humoral Functional Evolution Tracks with SARS-CoV-2 Mortality

One of the first papers to deeply study the serological correlates of SARS-CoV-2 infection, finding IgG class switching timing to be very important.

Related: Selective functional antibody transfer into the breastmilk after SARS-CoV-2 infection

A study of the extent, assessed from serological measurements, to which anti-SARS-CoV-2 immunity is transferred via breastmilk.

Microtubule growth rates are sensitive to global and local changes in microtubule plus-end density

August 3rd, 2020, Current Biology
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Related: Changes in cytoplasmic volume are sufficient to drive spindle scaling

This study used a similar experimental setup to investigate the determinants of mitotic spindle sizing.

Related: Dynamic instability of microtubule growth

The seminal study by Mitchison & Kirschner that established microtubules as dynamic structures.

Projects

Project Screenshot
🐍python
Spateo
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A bioinformatics platform. Spateo is a 3D spatiotemporal modeling framework that enables the creation of molecular holograms of whole embryos, allowing for the study of organ ecology at a molecular level in 3D space over time. Spateo enables scalable, partial, non-rigid alignment, multi-slice refinement, and mesh correction to construct 3D holograms from sequential 2D slices. It also introduces digitization methods to uncover multi-level biology from subcellular to whole organ, identifying expression gradients along arbitrary axes. It models intercellular communication to identify genes downstream of cell-cell interaction. Lastly, Spateo introduces "morphometric vector fields" of cell migration and integrates spatial differential geometry to unveil molecular programs underlying this movement.
Project Screenshot
🐍python
JSMonitor
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A suite of terminal commands for quickly managing JavaScript/TypeScript project dependencies. Currently, this contains two tools: a dependency updater that fetches the latest versions of dependencies and devDependencies and installs them if outdated, and an import scanner that checks codebases for import statements that are not yet installed. These packages are installed, and the package file is updated accordingly. Stay tuned for further updates!
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🐍python
Orange
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A command-line tool for formatting and organizing JavaScript/TypeScript files and additional common file types found in JS/TS projects. Formats files with extensions .js, .jsx, .ts, .tsx, .vue, .html, and .json by default. Allows for custom Prettier config and ignore files to be used, (by specifying the path to --config flag) with fallback to a default configuration if none is provided.
Loading crane model...
💛javascript
💙typescript
3D Animation Toolbox
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Currently incomplete; a set of 3D asset objects and examples of animations involving 3D assets. Currently, includes basic particle animations (rain, snowflakes, fire, etc.), an interactive flock of birds, and an animation of origami cranes in flight (which was utilized in this website!). This is not yet complete; additional examples and usage tutorials will be added in the future.

Hobbies

Baking Sweet Treats

Black Forest Cake
Black Forest Cake
A birthday cake for a friend. Chocolate sponge, cherry liqueur syrup, whipped cream, chocolate bark, pitted cherries and chocolate shavings.
Peppermint Pizzazz
Peppermint Pizzazz
Chocolate espresso sponge, peppermint buttercream, dark chocolate ganache, candy cane brittle and white chocolate peppermint bark.
Hazelnut Symphony
Hazelnut Symphony
No special occasion unless a love of Nutella counts as a special occasion. Chocolate sponge, hazelnut & almond streusel, hazelnut mousse, dark chocolate ganache, dark chocolate & Nutella shards, pecan shavings, Ferrero Rocher.
Oreo Domes
Oreo Domes
Cookies & cream mousse hemispheres, Oreos (whole cookies and crumble), brownie round, vanilla mirror glaze, caramel syrup, lemon shavings, decorative Pirouette chocolate fudge wafer.
Ode to Reese's
Ode to Reese's
Even though I stopped trick-or-treating over a decade ago, I still like to put out candy for everyone else. One year I had enough leftover peanut butter cups to make a cake- chocolate sponge, peanut buttercream, milk chocolate ganache, decorative Reese's cups.
Yuletide on the Forest Floor
Yuletide on the Forest Floor
Created for a holiday party! Chocolate genoise sponge, chocolate chestnut whipped cream, dark chocolate ganache, meringue mushrooms, cranberry, decorative rosemary, sugar and simple syrup.

Culinary Adventures

Xīnnián Kuàilè (Happy New Year)
Xīnnián Kuàilè (Happy New Year)
A celebration of the Lunar New Year. Egg fried rice, pork potstickers, sweet potato puree, radish, pea shoots, pork char siu, panda-styled red bean bun, fried sesame balls with ube jam.
Soil, Sea and Sky
Soil, Sea and Sky
A dish that represents each of the highest-level ecological zones: terrestrial, marine and aerial! Honey garlic salmon, orzo, sirloin steak, broccolini, pea puree, king oyster mushroom, duck, toasted sesame, tomato pearls and a teriyaki sauce & parsley tree.
Elevated Thanksgiving
Elevated Thanksgiving
Decided to have fun on Friendsgiving with this elevated take on Thanksgiving dinner. Turkey roulade, mashed potatoes, potato pave, cranberry gel, assorted vegetables.
Mediterranean Medley
Mediterranean Medley
A miscellaneous Mediterranean mashup! Falafel, pita crisps, tzatziki, yogurt, harissa tahini, pomegranate, mango chutney, cucumber slaw, and basmati rice.
KBBQ Plate
KBBQ Plate
Galbi (Korean BBQ short rib), nasi goreng w/ fried egg, Chinese cabbage slaw with sweet & sour homemade Asian dressing.
Deconstructed Big Mac Meal
Deconstructed Big Mac Meal
Had some fun injecting a little flair into a staple of my childhood. NY strip steak, toasted sesame buns, butter lettuce, pickle, onion, `special sauce`, pommes puree, ketchup, Sprite in a wine glass (not pictured).

Running

No better way to clear your head and relax than with constant searing lung pain! Just kidding, kind of. I love endurance running and it's also my preferred mode of transit. It's my favorite way of exploring new places!

Cambridge Half Marathon 2023

Thanksgiving 10k

5k PR